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Cardiac Rhythm Management (CRM) Devices - Global Strategic Business Report

Price:
USD $4,500.00
ISBN/SKU #:
GIA-MCP6132
Research Group:
Global Industry Analysts
Date of Publication:
October 2011
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Summary

This report analyzes the worldwide markets for Cardiac Rhythm Management (CRM) Devices in US$ Million by the following Product Segments: Implantable Cardioverter Defibrillators (ICD), Pacemakers, External Defibrillators, and EP Catheterization, Mapping, and Ablation (CMA) devices. The report provides separate comprehensive analytics for the US, Europe, Asia-Pacific, and Rest of World.  Annual estimates and forecasts are provided for  the period  2009 through 2017. A six-year historic analysis is also provided for these markets. The report profiles 48 companies including many key and niche players such as Bard Electrophysiology, Biosense Webster, Inc., Biotronik GMBH & Co. KG, Boston Scientific Corporation, Medtronic, Inc., Medtronic CryoCath LP, Vitatron Nederland BV, Philips Healthcare, St. Jude Medical, Inc., and Sorin Group. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

TABLE OF CONTENTS

CARDIAC RHYTHM MANAGEMENT (CRM) DEVICES						MCP-6132
A GLOBAL STRATEGIC BUSINESS REPORT


                                            CONTENTS


  1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS                       1
      Study Reliability and Reporting Limitations                          1
      Disclaimers                                                          2
      Data Interpretation & Reporting Level                                2
       Quantitative Techniques & Analytics                                 3
      Product Definitions and Scope of Study                               3
       Implantable Cardioverter Defibrillators (ICD)                       3
       Pacemaker                                                           4
       External Defibrillators                                             4
       Electrophysiology (EP) Catheterization, Mapping, and Ablation
        (CMA)                                                              4

  2. INDUSTRY OVERVIEW                                                     5
      A Prelude                                                            5
      Cardiac Rhythm Management Devices - An Outlook                       5
       Implantable Cardioverter Defibrillators                             5
       Pacemakers                                                          6
       External Defibrillators                                             6
       EP Catheterization, Mapping, & Ablation (CMA)                       6
      Market Structure                                                     6
       Table 1: World Market for Cardiac Rhythm Management (CRM)
       Devices (2010): Percentage Breakdown of Annual Revenues by
       Companies (includes corresponding Graph/Chart)                      7

       Table 2: World Market for High Power CRM Devices (2010):
       Percentage Breakdown of Annual Revenues by Companies.
       (includes corresponding Graph/Chart)                                7

       Table 3: World Market for Low Power CRM Devices (2010):
       Percentage Breakdown of Annual Revenues by Companies(includes
       corresponding Graph/Chart)                                          7

       Table 4: World Market for Implantable Cardioverter
       Defibrillator (2010): Percentage Breakdown of Annual Revenues
       by Companies (includes corresponding Graph/Chart)                   8

       Table 5: World External Defibrillators Market (2010):
       Percentage Market Share Breakdown of Leading Players -
       Medtronic, Philips and Others (includes corresponding
       Graph/Chart) (includes corresponding Graph/Chart)                   8

       Table 6: World Market for Advanced Cardiac Resynchronization
       Therapy (CRT) Devices (2010): Percentage Market Share
       Breakdown of Leading Players - Medtronic, Boston Scientific
       (Guidant), St. Jude Medical, and Others (includes
       corresponding Graph/Chart)                                          8

  3. TRENDS & ISSUES                                                       9
      SSS and AV Block Incidence Triggers Demand for Pacemakers            9
      Infamous Product Recalls Throw Growth Off-track                      9
      Market Shapes Up After the Recall Shock                              10
       Regulatory Riders Knit to Ensure Greater Device Reliability         10
      Growing Proportion of Obese Population: A Major Demographic
       Driver                                                              10
      Replacements to Drive the Growth of ICDs                             11
      Developments in Energy-Based Therapies Augur Well for Cardiac
       Ablation Treatments                                                 11
      Expanding Applications Lend Traction to Growth                       12
      Prices of Cardiac Pacemakers Soften                                  12
      Heart Patients Using ICD, Enjoy Satisfactory Quality Life            12
      Pacemakers Ensure Effective Management of Non-Systolic Heart
       Failures                                                            13
      CRT: An Effective Treatment for Bradycardia, Tachycardia &
       Fibrillation                                                        13
      ICDs in Pediatric Care Shows Promise                                 13
      Emerging Therapies for the Treatment of Atrial Fibrillation          14
      New Generation CRM Devices Feature Superior Benefits                 14
      MRI-Compatible Pacemakers & ICDs                                     14
      Resistance Against Electronic Interferences                          15
      Confusion Over the Use of CRM Devices Threaten Perceived
       Effectiveness                                                       15
      Breathing Disorders in Patients Implanted with Pacemakers: A
       Cause for Concern                                                   16
      Approval of Untested Pacemaker Connectors Raises Eyebrows            17
      ICD Lead Failure Demands Immediate Attention                         17
      Pacemaker Hacking Has the Industry Up by Its Ears                    17
      Pacemakers Face Stiff Competition from CRT-D Devices                 18
      ICDs More Prone to Malfunction than Pacemakers                       18
       Conclusion                                                          19
      Technology Innovation: A Futuristic Rumination                       19
       The Heart to Power CRM Devices: The Future of CRM Therapies         19
       Genetic Advances to Yield Replacement for Pacemakers                19
       Ablation Technology Undergoing Innovations                          20
       Vein Ablation Catheter Proves Successful in Cases of
        Paroxysmal Atrial Fibrillation                                     20
       Ablation Therapy Useful in Treating Persistent/ Permanent
        Atrial Fibrillation (PPAF)                                         20
       Magnetic Navigation: An Innovation in Catheter Ablation             21
       New Force-Sensing Ablation Catheter Aims to Aid Physician
        Decision Making                                                    21
       Pricing & Reimbursements: Critical Determinants of Growth           22
       New Guidelines Issued for Safe Management of CRM Devices in
        the US and Europe                                                  22

  4. PRODUCT OVERVIEW                                                      24
      Sudden Cardiac Arrest: A Leading Cause of Death                      24
      Cardiac Rhythm Management (CRM): A Definition                        24
       Implantable Cardioverter Defibrillators (ICDs)                      24
        Surgical Implantation of ICDs: The Procedure                       25
        ICDs - The Benefits                                                25
        Types of ICDs                                                      26
        ICDs: An Evolution Scan                                            26
        Complications Associated With ICD Usage                            26
        CRT-D - A New Therapeutic Device                                   26
       Pacemakers                                                          27
        Surgical Implantation of Pacemakers: The Procedure                 27
        Types of Pacemakers                                                27
        Methods of Pacing                                                  28
         Fixed Rate Pacemakers                                             28
         Demand Pacemakers                                                 28
         Rate-Responsive Pacemaker                                         28
        Pacemakers: An Evolution Scan                                      28
        Complications Associated with Pacemakers                           29
        Advent of CRT-P                                                    29
       Electrophysiology (EP) Catheterization, Mapping, and Ablation
        (CMA)                                                              29
        The Ablation Procedure                                             30
       External Defibrillators                                             30
        Types of AEDs                                                      31
      Cardiac Rhythm Disorders: A Brief Review                             31
       Cardiac Arrhythmias                                                 31
        Classification of Cardiac Arrhythmias                              32
         Bradycardia                                                       32
         Tachycardia                                                       32
         Atrial Fibrillation                                               33
       Heart Blocks                                                        34
       Syncope                                                             34
       Sick Sinus Syndrome                                                 34
       Cardiomyopathy                                                      34

  5. PRODUCT APPROVALS/INTRODUCTIONS                                       35
      Boston Scientific Unveils CRM Connector System                       35
      Biosense Catheter Receives FDA Marketing Approval                    35
      St. Jude Medical Secures Approval for Atlas II ICD from Japan        35
      Zoll Medical Defibrillators Receive FDA Clearance                    35
      St. Jude Medical Receives CE Mark for Integrated Irrigation
       Pump and Ablation Generator                                         36
      AtriCure Secures FDA 510(k) Approval for Coolrail Device             36
      Hansen Medical Gains FDA Approval for CoHesion™ Module               37
      St. Jude Medical Obtains CE Mark and FDA Approval for HIFU
       Surgical Ablation Solutions                                         37
      Biosense Releases NAVISTAR® RMT THERMOCOOL® Catheter                 37
      Atricure Unveils The ORLab™                                          38
      Cardima Receives SFDA Approval to Market INTELLITEMP® in China       38
      ZOLL Obtains 510K Clearance to Sell and Market Zoll R Series
       Code-Ready Defibrillator                                            38
      ST. Jude Medical Obtains FDA and CE Mark Approval for New
       Epicor LP Cardiac Ablation System                                   39
      Cardima Obtains Approval for Marketing Surgical Ablation
       System in Thailand                                                  39
      ATS Medical Introduces First CryoMaze Surgical Ablation Clamp        39
      CardioNet Unveils New Reporting Package for Atrial
       Fibrillation Treatment                                              40
      Boston Scientific Defibrillator Receives CE Mark Approval            40
      TyRx Introduces New Anti-bacterial Envelope, AIGISRX™ ICD            40
      St. Jude Medical Receives Approval from Japanese MHLW                41
      Boston Scientific Secures FDA Approval for CRM Solutions             41
      Sorin Group Develops New-Generation CRT-D Implants                   41
      BSC Secures CE Mark Approval for ALTRUA Pacemakers                   42
      Medtronic Secures FDA Approval for New Vision 3D Devices             42
      Medtronic Obtains FDA Approval for Software Update                   43
      St. Jude Medical Obtains FDA Approval for SJM Cardiac Monitor        43
      Boston Scientific Obtains Approval For Cognis CRT-D And
       Teligen ICD                                                         43
      FDA Approves Medtronic’s Medtronic Sprint Quattro Secure® S Lead     43
      Medtronic Obtains CE Mark Approval for Pacemaker and Pacing Leads    44
      St. Jude Medical Obtains Japanese Approval for Victory®
       Pacemakers Family                                                   44
      Sorin Group Obtains Approval For Isoline Defibrillation Leads
       In Japan                                                            44
      BSC Secures FDA Approval for New ALTRUA Pacemakers                   45
      St. Jude Medical Obtains Approval for Durata Defibrillation Lead     46
      St. Jude Medical Obtains Japanese Approval for Durata
       Defibrillation Lead                                                 46
      St. Jude Medical Obtains Japanese Approval for Victory Family
       of Pacemakers                                                       46
      Sorin Group Gains FDA Approval for OVATIO™                           46
      Sorin SpA Gains FDA Approval for REPLY                               47
      Medtronic Receives Approval for Lead Integrity Alert™                47
      Physio-Control Gains FDA Approval for LIFEPAK® 20e
       Defibrillator/Monitor                                               47
      TyRx Introduces New Anti-Bacterial Envelope, AIGISRX™ ICD            48
      LifeWatch Introduces Next-Generation Monitor, LifeStar ACT III
       Platinum                                                            48
      eCardio Launches eVolution, New Cardiac Monitoring System            48
      Philips Introduces PageWriter TC70 Cardiograph                       49
      Sorin Group Announces Commercial Release and First Implant of
       PARADYM™ CRT 8750                                                   49
      St. Jude Medical Introduces QuickOpt® Timing Cycle
       Optimization in CRT-D                                               49
      Cardiac Science Unveils Simple Electronic Reporting System           50
      Mennen Medical Introduces VitaLogik® 4000 Line                       50
      BIOTRONIK Releases CRT-P in US Market                                51
      Vermed Releases Defibrillation Pads Series and Universal
       Connector System                                                    51
      St. Jude Releases Reflexion Spiral X™ in US                          52

  6. RECENT INDUSTRY ACTIVITY                                              53
      Novation Partners St. Jude Medical for CRM Products                  53
      Medtronic Sets Up Production Unit in Singapore                       53
      Novation Collaborates with BIOTRONIK                                 53
      Boston Scientific Inks Agreement with Fukuda Denshi                  53
      Creganna Closes Tactx Medical Acquisition                            54
      Medtronic Takes Over Ablation Frontiers                              54
      Sorin Enters into Agreement with Orange Business Services            54
      Philips Signs a Deal with Bard Electrophysiology                     55
      Boston Scientific Bags CRM Contract from Dept. of Veterans
       Affairs                                                             55
      Medtronic and Boston Scientific Inks Agreement to End IP Disputes    55
      St Jude Medical to Invest in Penang                                  56
      Cardima Enters into a Distribution Agreement with Peerless
       Medical                                                             56
      Cardiac Science Enters into an Alliance with Boy Scouts of
       America                                                             56
      Cardima Enters into a New Strategic Surgical Alliance with
       Biocore                                                             57
      Cardima Enters into a New Strategic Marketing Alliance with
       On-X Life Technologies                                              57
      Welch Allyn and ZOLL Medical Corporation Collaborate                 58
      Cardima Selects Dot Medical to Distribute Its EP Products in
       the UK                                                              58
      Royal Philips to Guide ‘euHeart’ Project                             59
      Target Center Acquires HeartSine® Defibrillators                     59
      St Jude Medical Acquires EP MedSystems                               59
      St. Jude Takes Over Radi Medical AB                                  59
      Medrad to Acquire Possis                                             60
      Phoenix Acquires Stake in Possis                                     60
      Biotronik Acquires VascoMed                                          60
      Medtronic Takes Over CryoCath Technologies                           61
      Boston Scientific Takes Over CryoCor                                 61
      St. Jude Completes Acquisition of MediGuide                          61
      Greatbatch Enters Into A Strategic Partnership With Issys            61
      Sorin Group Inks Collaborative Agreement with Greatbatch             62
      Philips Enters into MOU with King’s College London on Research
       Collaboration                                                       62
      Welch Allyn Collaborates with ZOLL Medical Corporation               62
      ZOLL and HealthTrust Sign Purchasing Deal                            63
      ZOLL Inks Multi-Year Agreement with Masimo                           63
      First Responder Wins Contract from Harvard School of Public
       Health                                                              63
      Beijing Airport Group to Deploy ZOLL AED Plus Solutions              63
      STH NHS Trust to Deploy New R Series BLS Solutions of ZOLL           64
      Major EMS Centers in China Deploys ZOLL M Series Defibrillator       64
      DRF to Deploy corpuls3 Heart Defibrillators                          65
      Riedel & Schulz and GS Elektromed Distributes 8 corpuls3
       Medical Units                                                       65
      Trivitron Inks Marketing And Distribution Agreement With
       Boston Scientific                                                   65
      CardioComm Signs Licensing Agreement with GE Healthcare              65
      Cambridge Heart Licenses Technology for Implantable Devices          65
      Synovis Life Technologies to Divest Interventional Business          66
      Boston Scientific Divests Cardiac Surgery And Vascular Surgery
       Businesses                                                          66
      Sorin Group Sells Its Vascular Therapy Business to CIDl              66

  7. FOCUS ON SELECT PLAYERS                                               67
      Bard Electrophysiology (US)                                          67
      Biosense Webster, Inc. (US)                                          67
      Biotronik GMBH & Co. KG (Germany)                                    67
      Boston Scientific Corporation (US)                                   67
      Medtronic, Inc. (US)                                                 68
       Medtronic CryoCath LP (US)                                          68
       Vitatron Nederland BV (Netherlands)                                 68
      Philips Healthcare (The Netherlands)                                 69
      St. Jude Medical, Inc. (US)                                          69
      Sorin Group (Italy)                                                  69

  8. GLOBAL MARKET PERSPECTIVE                                             70
      Table 7: World Recent Past, Current & Future Analysis for
      Cardiac Rhythm Management Devices by Geographic Region - US,
      Europe, Asia-Pacific and Rest of World Markets Independently
      Analyzed with Annual Sales Figures in US$ Million for Years
      2009 through 2017 (includes corresponding Graph/Chart)               70

      Table 8: World Historic Review for Cardiac Rhythm Management
      Devices by Geographic Region - US, Europe, Asia-Pacific and
      Rest of World Markets Independently Analyzed with Annual Sales
      Figures in US$ Million for Years 2003 through 2008 (includes
      corresponding Graph/Chart)                                           71

      Table 9: World 15-Year Perspective for Cardiac Rhythm
      Management Devices by Geographic Region - Percentage Breakdown
      of Dollar Sales for US, Europe, Asia-Pacific and Rest of World
      Markets for Years 2003, 2010 & 2017 (includes corresponding
      Graph/Chart)                                                         72

      Table 10: World Recent Past, Current & Future Analysis for
      Implantable Cardioverter Defibrillators by Geographic Region -
      US, Europe, Asia-Pacific and Rest of World Markets
      Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2009 through 2017 (includes corresponding
      Graph/Chart)                                                         73

      Table 11: World Historic Review for Implantable Cardioverter
      Defibrillators by Geographic Region - US, Europe, Asia-Pacific
      and Rest of World Markets Independently Analyzed with Annual
      Sales Figures in US$ Million for Years 2003 through 2008
      (includes corresponding Graph/Chart)                                 74

      Table 12: World 15-Year Perspective for Implantable
      Cardioverter Defibrillators by Geographic Region - Percentage
      Breakdown of Dollar Sales for US, Europe, Asia-Pacific and
      Rest of World Markets) for Years 2003, 2010 & 2017 (includes
      corresponding Graph/Chart)                                           75

      Table 13: World Recent Past, Current & Future Analysis for
      Pacemakers by Geographic Region - US, Europe, Asia- Pacific
      and Rest of World Markets Independently Analyzed with Annual
      Sales Figures in US$ Million for Years 2009 through 2017
      (includes corresponding Graph/Chart)                                 76

      Table 14: World Historic Review for Pacemakers by Geographic
      Region - US, Europe, Asia-Pacific and Rest of World Markets
      Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2003 through 2008 (includes corresponding
      Graph/Chart)                                                         77

      Table 15: World 15-Year Perspective for Pacemakers by
      Geographic Region - Percentage Breakdown of Dollar Sales for
      US, Europe, Asia-Pacific and Rest of World Markets) for Years
      2003, 2010 & 2017 (includes corresponding Graph/Chart)               78

      Table 16: World Recent Past, Current & Future Analysis for
      External Defibrillators by Geographic Region - US, Europe,
      Asia-Pacific and Rest of World Markets Independently Analyzed
      with Annual Sales Figures in US$ Million for Years 2009
      through 2017 (includes corresponding Graph/Chart)                    79

      Table 17: World Historic Review for External Defibrillators by
      Geographic Region - US, Europe, Asia-Pacific and Rest of World
      Markets Independently Analyzed with Annual Sales Figures in
      US$ Million for Years 2003 through 2008 (includes
      corresponding Graph/Chart)                                           80

      Table 18: World 15-Year Perspective for External
      Defibrillators by Geographic Region - Percentage Breakdown of
      Dollar Sales for US, Europe, Asia-Pacific and Rest of World
      Markets) for Years 2003, 2010 & 2017 (includes corresponding
      Graph/Chart)                                                         81

      Table 19: World Recent Past, Current & Future Analysis for EP
      Catheterization, Mapping, & Ablation (CMA) by Geographic
      Region - US, Europe, Asia-Pacific and Rest of World Markets
      Independently Analyzed with Annual Sales Figures in US$
      Million for Years 2009 through 2017 (includes corresponding
      Graph/Chart)                                                         82

      Table 20: World Historic Review for EP Catheterization,
      Mapping, & Ablation (CMA)by Geographic Region - US, Europe,
      Asia-Pacific and Rest of World Markets Independently Analyzed
      with Annual Sales Figures in US$ Million for Years 2003
      through 2008 (includes corresponding Graph/Chart)                    83

      Table 21: World 15-Year Perspective for EP Catheterization,
      Mapping, & Ablation (CMA) by Geographic Region - Percentage
      Breakdown of Dollar Sales for US, Europe, Asia-Pacific and
      Rest of World Markets) for Years 2003, 2010 & 2017 (includes
      corresponding Graph/Chart)                                           84

  9. THE UNITED STATES                                                     85
      A.Market Analysis                                                    85
        Outlook                                                            85
        Market Overview                                                    85
         Demand for Automated External Defibrillators Shoots Up in
          the US                                                           85
         Market Share Statistics                                           86
          Table 22: US Market for (ICD) Implantable Cardioverter
          Defibrillators (2011): Percentage Breakdown of Annual
          Revenues by Companies (includes corresponding Graph/Chart)       86

          Table 23: US Market for Core Pacemakers & CRT-P (2010):
          Percentage Breakdown of Annual Revenues by Companies
          (includes corresponding Graph/Chart)                             86
         Cardiovascular Disease Incidence Statistics                       86
          Table 24: Cardiovascular Diseases in US (2010): Percentage
          Breakdown of Total Economic Cost Incurred for Treatment by
          Disease Type (includes corresponding Graph/Chart)                86

          Table 25: Cardiovascular Diseases in US (2010): Percentage
          Breakdown of Total Economic Cost Incurred for Treatment by
          Type of Expenditure (includes corresponding Graph/Chart)         87

          Table 26: Cardiovascular Diseases (CvD) in US (2010):
          Incidence of CvDs in Adult Population Segregated by Age
          and Gender (includes corresponding Graph/Chart)                  87

          Table 27: Cardiovascular Diseases (CvD) in the US (2010):
          Percentage Breakdown of Deaths by Type of Causal CvD
          (includes corresponding Graph/Chart)                             88
      B.Market Analytics                                                   89
        Table 28: US Recent Past, Current & Future Analysis for
        Cardiac Rhythm Management Devices by Product Segment -
        Implantable Cardioverter Defibrillators, Pacemakers,
        External Defibrillators, and EP Catheterization, Mapping,
        and Ablation (CMA) Markets Independently Analyzed with
        Annual Sales Figures in US$ Million for Years 2009 through
        2017 (includes corresponding Graph/Chart)                          89

        Table 29: US Historic Review for Cardiac Rhythm Management
        Devices by Product Segment - Implantable Cardioverter
        Defibrillators, Pacemakers, External Defibrillators, and EP
        Catheterization, Mapping, and Ablation (CMA) Markets
        Independently Analyzed with Annual Sales Figures in US$
        Million for Years 2003 through 2008 (includes corresponding
        Graph/Chart)                                                       90

        Table 30: US 15-Year Perspective for Cardiac Rhythm
        Management Devices by Product Segment - Percentage Breakdown
        of Dollar Sales for Implantable Cardioverter Defibrillators,
        Pacemakers, External Defibrillators, and EP Catheterization,
        Mapping, and Ablation (CMA) for Years 2003, 2010 & 2017
        (includes corresponding Graph/Chart)                               91

  10. EUROPE                                                               92
      A.Market Analysis                                                    92
        Outlook                                                            92
        Major Market Trends                                                92
         Flourishing Market for CRM Market in Western Europe               92
         Bright Future for CRM Devices Industry                            92
         Highly Competitive External Defibrillators Market Paves Way
          for Consolidations                                               93
         Strong Demand for Implantable Cardiac Defibrillators in UK        93
      B.Market Analytics                                                   94
        Table 31: European Recent Past, Current & Future Analysis
        for Cardiac Rhythm Management Devices by Product Segment -
        Implantable Cardioverter Defibrillators, Pacemakers,
        External Defibrillators, and EP Catheterization, Mapping,
        and Ablation (CMA) Markets Independently Analyzed with
        Annual Sales Figures in US$ Million for Years 2009 through
        2017 (includes corresponding Graph/Chart)                          94

        Table 32: European Historic Review for Cardiac Rhythm
        Management Devices by Product Segment - Implantable
        Cardioverter Defibrillators, Pacemakers, External
        Defibrillators, and EP Catheterization, Mapping, and
        Ablation (CMA) Markets Independently Analyzed with Annual
        Sales Figures in US$ Million for Years 2003 through 2008
        (includes corresponding Graph/Chart)                               95

        Table 33: European 15-Year Perspective for Cardiac Rhythm
        Management Devices by Product Segment - Percentage Breakdown
        of Dollar Sales for Implantable Cardioverter Defibrillators,
        Pacemakers, External Defibrillators, and EP Catheterization,
        Mapping, and Ablation (CMA) for Years 2003, 2010 & 2017
        (includes corresponding Graph/Chart)                               96

  11. ASIA PACIFIC                                                         97
      A.Market Analysis                                                    97
        Outlook                                                            97
        Major Market Trends                                                97
         Increasing Heart Diseases Spur Demand for CRM Devices             97
         Chinese CRM Market to Witness Robust Growth                       97
      B.Market Analytics                                                   98
        Table 34: Asia Pacific Recent Past, Current & Future
        Analysis for Cardiac Rhythm Management Devices by Product
        Segment - Implantable Cardioverter Defibrillators,
        Pacemakers, External Defibrillators, and EP Catheterization,
        Mapping, and Ablation (CMA) Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2009
        through 2017 (includes corresponding Graph/Chart)                  98

        Table 35: Asia Pacific Historic Review for Cardiac Rhythm
        Management Devices by Product Segment - Implantable
        Cardioverter Defibrillators, Pacemakers, External
        Defibrillators, and EP Catheterization, Mapping, and
        Ablation (CMA) Markets Independently Analyzed with Annual
        Sales Figures in US$ Million for Years 2003 through 2008
        (includes corresponding Graph/Chart)                               99

        Table 36: Asia Pacific 15-Year Perspective for Cardiac
        Rhythm Management Devices by Product Segment - Percentage
        Breakdown of Dollar Sales for Implantable Cardioverter
        Defibrillators, Pacemakers, External Defibrillators, and EP
        Catheterization, Mapping, and Ablation (CMA) for Years 2003,
        2010 & 2017 (includes corresponding Graph/Chart)                   100

  12. REST OF WORLD                                                        101
      A.Market Analysis                                                    101
        Outlook                                                            101
        Market Share Statistics                                            101
         Table 37: Implantable Cardioverter Defibrillator (ICD)
         Market in EMEA, Asia, & South America (2010): Percentage
         Market Share Breakdown of Leading Players - Medtronic,
         Boston Scientific (Guidant), St Jude Medical, and Others
         (includes corresponding Graph/Chart)                              101

         Table 38: Core Pacemakers & CRT-P Market in EMEA, Asia, &
         South America (2010): Percentage Market Share Breakdown of
         Leading Players - Medtronic, St. Jude, Boston Scientific
         and Others (includes corresponding Graph/Chart)                   101
      B.Market Analytics                                                   102
        Table 39: Rest of World Recent Past, Current & Future
        Analysis for Cardiac Rhythm Management Devices by Product
        Segment - Implantable Cardioverter Defibrillators,
        Pacemakers, External Defibrillators, and EP Catheterization,
        Mapping, and Ablation (CMA) Markets Independently Analyzed
        with Annual Sales Figures in US$ Million for Years 2009
        through 2017 (includes corresponding Graph/Chart)                  102

        Table 40: Rest of World Historic Review for Cardiac Rhythm
        Management Devices by Product Segment - Implantable
        Cardioverter Defibrillators, Pacemakers, External
        Defibrillators, and EP Catheterization, Mapping, and
        Ablation (CMA) Markets Independently Analyzed with Annual
        Sales Figures in US$ Million for Years 2003 through 2008
        (includes corresponding Graph/Chart)                               103

        Table 41: Rest of World 15-Year Perspective for Cardiac
        Rhythm Management Devices by Product Segment - Percentage
        Breakdown of Dollar Sales for Implantable Cardioverter
        Defibrillators, Pacemakers, External Defibrillators, and EP
        Catheterization, Mapping, and Ablation (CMA) for Years 2003,
        2010 & 2017 (includes corresponding Graph/Chart)                   104


  COMPETITIVE LANDSCAPE

     Total Companies Profiled: 48 (including Divisions/Subsidiaries - 125)

     ------------------------------------------
     Region/Country                     Players
     ------------------------------------------
     The United States                     30
     Canada                                 7
     Japan                                  8
     Europe                                67
      France                                8
      Germany                              13
      The United Kingdom                    8
      Italy                                 7
      Spain                                 5
      Rest of Europe                       26
     Asia-Pacific (Excluding Japan)        10
     Latin America                          2
     Africa                                 1
     ------------------------------------------

Additional Information

Number of Pages: 375

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