Global Markets for Nanoparticle Size Analysis Instrumentation in the Life Sciences

Global Markets for Nanoparticle Size Analysis Instrumentation in the Life Sciences

Date of Publication: Aug 20, 2014, 166 Pages
US$6,650.00
GB-BIO114B

Global Markets for Nanoparticle Size Analysis Instrumentation in the Life Sciences

This study provides a comprehensive analysis of the global market for nanoparticle size and characterization analysis instrumentation in the life sciences. Forecasts are provided by product, product category and by company from 2012 through 2019.Detailed instrument product and technical measurements analyses, characterization of biopharmaceutical and biological product, to overall industry trends, in order to qualify and quantify the market for analytical instrumentation used for nanoparticle analysis is covered in this report.

Use this report to:
- Identify the specific classes of nanoparticles instrumentation and the pharmaceutical and biotechnology products associated with them.
- Receive analysis of the market for nanoparticle size and characterization analysis instrumentation in the life sciences on a global basis.
- Receive a range of information from detailed instrument product analyses, technical measurements analyzed, to overall industry trends.
- Learn about the companies poised to introduce products in the industry during the forecast period and how these introductions will change the face of the competitive
environment.

Highlights
- The global market for nanoparticles instrumentation in life sciences was $5.6 billion in 2013. This value is expected to increase to $5.9 billion in 2014 and about $7.8 billion by 2019, a compound annual growth rate (CAGR) of 5.7% for the five-year period, 2014 to 2019.
- Electron microscopy as a segment is expected to reach $2.4 billion in 2014. It is further projected to grow to nearly $2.9 billion in 2019, with a CAGR of 4.2% for the five-year period, 2014 to 2019.
- Optical microscopy as a segment is expected to reach $1.7 billion in 2014. It is further projected to grow to about $2.3 billion in 2019, with a CAGR of 5.9% for the five-year period, 2014 to 2019.

INTRODUCTION

STUDY GOALS AND OBJECTIVES
This study provides a comprehensive analysis of the market for nanoparticle size and characterization analysis instrumentation in the life sciences on a global basis. Particular attention is given to drug development, formulation and quality control application in the production of life sciences products, drugs, biologicals and nanoparticle applications. Its aim is to provide a range of information, from detailed instrument product analyses, technical measurements analyzed, biopharmaceutical and biological product characterization, to overall industry trends, in order to qualify and quantify the market for analytical instrumentation used for nanoparticle analysis. The applicability of specific types of nanoparticle instrumentation for specific applications is discussed. Forecasts and trends are developed from a cross reference of data points, gleaned
from proprietary industry sources, company publications, industry benchmarking and other divergent data sources to arrive at a cogent and coordinated forecast.

REASONS FOR DOING THE STUDY
For companies with an effective strategy, market opportunity awaits. Importantly, the ability to develop an effective strategy begins with where opportunity exists and ends
with how to effectively execute to capture profit from opportunity. The nanoparticle analysis market presents an increasingly significant part of the overall pharmaceutical product analysis market worldwide. This study investigates the specific classes of nanoparticles instrumentation and the pharmaceutical/ biotechnology products associated with them. Existing instrument products and potential new instrument or new methods of analysis in the pipelines of the major instrumentation players in this market are reviewed.

Growing health concerns in developing countries are expected to continue to contribute substantially to market growth for biopharmaceuticals. This growth will stimulate growth in the instrumentation segment and is forecast for the period of 2014 to 2019. This report analyzes emerging markets by technology category. Continued growth is expected in emerging geographies, driven by the health awareness of the growing middle class in emerging countries such as India, China, Brazil and Russia. This report seeks to address the critically important topics of analyzing a changing market dynamic, emerging players and products, strategies for accessing emerging markets, specific instrument companies and global geographies in order to allocate resources and make effective decisions.

SCOPE OF REPORT
Current and projected product forecasts during the forecast period (2014 to 2019) are discussed. New product launches will be discussed. Revenue figures for 2013 are actual figures, except where actual results have not been reported, due to the timing of the release of this report. The report includes analysis of leading and emerging nanoparticle instrumentation categories. Profiles of manufacturers of leading products and their specific products are provided. This report also assesses companies poised to introduce products during the forecast period and discusses how these introductions will change the face of the competitive environment.

Market figures are based on revenues at the manufacturers’ level and are projected at 2013-dollar value. Inflation is not computed into the projection figures. Trends are
assessed based on projected sales for existing products, for new product introductions, expanded markets for existing products and other factors affecting the market. Included in this report are forecasts by product, product category and by company from 2012 through 2019. The study is arranged to offer an overview of existing nanoparticle instrumentation technology, company, geography and mechanism of analysis with forecasts broken down and covered by geographic region or country. Patent information is reviewed for various technologies. The status of approvals by regulatory agencies, where appropriate, is reviewed. Figures are reported in U.S. dollars and in each case reflect currency fluctuations within the performance of revenue change. Revenue figures do not account for variation in local currencies. All market share data presented is on a global basis, unless specifically noted.

INTENDED AUDIENCE
This report is an invaluable tool for business planners, acquisition specialists, licensing strategists, product managers, market research analysts, investors, investor consultants and anyone interested in the nanoparticle analytical instrumentation and its impact on the biological drug market, its products, its industry participants and its
future. The importance of identifying overall market trends, product opportunities, emerging geographies, merger and acquisition (M&A) opportunities and insights that provide guidance for sales growth or defensive moves cannot be overstated for a variety of constituents, including:

- Established companies in the industry will benefit from the contents, including corporate strategy, sales and marketing, business development and R&D.
- Emerging players in the segment must understand specific opportunities for out-licensing, originating from the elements of differentiation of their product or
technology as compared to leading, competitive and emerging products. As well, market forecasts can support investment, provided a thorough and detailed
substantiation is provided for the market forecast, as is found in this study.
- Investment firms evaluating candidates for venture capital or hedged investments will gain insights as to the opportunity and risks that are being encountered in the
industry, in a product and company specific analysis.
- Equity analysts are provided detailed forecasts for the next five years, substantiated by quantitative analysis that can support further analysis to product and company
forecasts over the short and long run.

TABLE OF CONTENTS

CHAPTER 1
INTRODUCTION 2

STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THE STUDY 2
SCOPE OF REPORT 3
INTENDED AUDIENCE 3
METHODOLOGY AND INFORMATION SOURCES 4
ANALYST'S CREDENTIALS 5
DISCLAIMER 5
CHAPTER 2 SUMMARY 7
SUMMARY TABLE GLOBAL MARKET FOR LIFE SCIENCE NANOPARTICLE ANALYSIS
EQUIPMENT, THROUGH 2019 ($ MILLIONS) 8
SUMMARY FIGURE GLOBAL MARKET FOR LIFE SCIENCE NANOPARTICLE ANALYSIS
EQUIPMENT, 2012-2019 ($ MILLIONS) 8
CHAPTER 3 OVERVIEW 11
BASICS OF NANOPARTICLES IN THE LIFE SCIENCES 11
BASICS OF PARTICLE ANALYSIS FOR BIOACTIVE NANOPARTICLES 12
PARTICLE SIZE ANALYSIS 13
PARTICLE SHAPE ANALYSIS 14
DRUG RELEASE FROM NANOPARTICLES 15
PARTICLE MOLECULAR WEIGHT ANALYSIS 15
PARTICLE ZETA POTENTIAL ANALYSIS 16
PARTICLE RHEOLOGY ANALYSIS 16
PARTICLE IMAGING ANALYSIS 16
SCANNING ELECTRON MICROSCOPE 17
TRANSMISSION ELECTRON MICROSCOPE 17
PARTICLE MOLECULAR STRUCTURE 17
ATOMIC FOCUS MICROSCOPE 18
SCANNING TUNNELING ELECTRON MICROSCOPE 19
FLOW CYTOMETRY 19
COMPANIES USING NANOPARTICLE SIZING INSTRUMENTATION 20
TABLE 1 BIOPHARMA COMPANIES UTILIZING NANOPARTICLE CHARACTERIZATION
INSTRUMENTATION 20
TABLE 2 BIOPHARMA AND BIOTECHNOLOGY COMPANIES APPLYING NANOPARTICLE
TECHNOLOGY 22
CHAPTER 4 GLOBAL LIFE SCIENCES MARKET FOR NANOPARTICLE ANALYSIS
INSTRUMENTATION 25
NANOPARTICLE ANALYSIS MARKET 25
TABLE 3 MARKET FOR NANOPARTICLES ANALYSIS EQUIPMENT, THROUGH 2019 ($
MILLIONS) 26
GROWTH OF NANOPARTICLE INSTRUMENTATION BY INDUSTRY SEGMENT 27
TABLE 4 PROJECTED GROWTH OF ANALYTICAL INSTRUMENTATION SEGMENTS,
2013-2014 (%) 27
GROWTH OF NANOPARTICLE INSTRUMENTATION BY GLOBAL REGION 28
TABLE 5 GLOBAL GROWTH RATE FOR ANALYTICAL/LIFE SCIENCES
INSTRUMENTATION BY REGION, 2014-2019 (%) 28
COMPANIES USING NANOPARTICLE ANALYSIS INSTRUMENTATION 29
TABLE 6 BIOPHARMA COMPANIES UTILIZING NANOPARTICLE CHARACTERIZATION
INSTRUMENTATION 29
TABLE 7 COMPANIES SUPPORTING NANOPARTICLE USE IN THE LIFE SCIENCES 29
CHAPTER 5 PARTICLE SIZE ANALYSIS 32
INTRODUCTION 32
REVENUE FROM NANOPARTICLE IDENTIFICATION INSTRUMENTATION 33
TABLE 8 REVENUE FROM NANOPARTICLE IDENTIFICATION INSTRUMENTATION,
THROUGH 2019 ($ MILLIONS) 33
PARTICLE TYPE, SIZE AND SHAPE 33
TABLE 9 NANOPARTICLES CURRENTLY USED IN DRUG DELIVERY AND DIAGNOSTIC
IMAGING 34
TABLE 10 SPHERICITY LEVELS FOR NANOPARTICLE CHARACTERIZATION 35
TABLE 11 GOLD NANOPARTICLE SHAPES IN RESPONSE TO DNA BASES 36
PARTICLE SIZE ANALYSIS 36
TABLE 12 NANOPARTICLE SIZING METHODS USED IN PHARMACEUTICAL INDUSTRY 38
PARTICLE SIZING BY STATIC LIGHT SCATTERING 38
PARTICLE SIZING BY DYNAMIC LIGHT SCATTERING 39
NONINVASIVE BACK SCATTER METHOD 40
PHOTON CORRELATION SPECTROSCOPY 41
CONDENSATION PARTICLE COUNTER (CPC) 41
NANOPARTICLE TRACKING ANALYSIS 42
STRENGTHS AND WEAKNESSES OF INDIVIDUAL INSTRUMENTATION TYPES 44
TABLE 13 STRENGTHS AND WEAKNESSES OF SOME NANOPARTICLE SIZING
METHODS 44
APPLICATION OF PARTICLE SIZE INFORMATION 45
NANOPARTICLE SIZING INSTRUMENTATION 47
TABLE 14 NANOPARTICLE SIZING INSTRUMENTATION 48
NANOPARTICLE SIZING INSTRUMENT MAJOR PLAYERS 50
TABLE 15 NANOPARTICLE SIZING MAJOR PLAYERS 50
CHAPTER 6 NANOPARTICLE SHAPE ANALYSIS IN LIFE SCIENCES 53
NANOPARTICLE SHAPE ANALYSIS 53
TABLE 16 CHARACTERISTICS OF VARIOUS FORMS OF NANOPARTICLES 54
GOLD AND SILVER NANOPARTICLE SHAPES 55
TABLE 17 COLOR CHANGE AS A FUNCTION OF PARTICLE SIZE FOR GOLD
NANOPARTICLES 55
TABLE 18 GOLD NANOPARTICLE SHAPES FORMED IN RESPONSE TO SPECIFIC DNA
BASES 56
TABLE 19 COLOR CHANGE AS A FUNCTION OF PARTICLE SIZE FOR SILVER
NANOPARTICLES 56
NANOPARTICLE SHAPE ANALYSIS METHODS 57
TABLE 20 ASPECT RATIOS FOR CERTAIN NANOPARTICLE SHAPES 58
ELECTRON IMAGING METHODS FOR PARTICLE SHAPE ANALYSIS 60
TRANSMISSION ELECTRON MICROSCOPY 60
TABLE 21 COMPARISON OF SPECIFICATION OF OPTICAL MICROSCOPE AND TEM 61
SCANNING ELECTRON MICROSCOPE 62
X-RAY DETECTORS 63
APPLICATION OF NANOPARTICLE SIZE INFORMATION 64
INSTRUMENTATION FOR NANOPARTICLE SHAPE ANALYSIS 65
TABLE 22 COMPARISON OF SPECIFICATION OF A SEM TO OPTICAL MICROSCOPE 66
TABLE 23 NANOPARTICLE SHAPE INSTRUMENTS 67
TABLE 24 TEM AND SEM INSTRUMENTATION FOR NANOPARTICLE ANALYSIS 69
CHAPTER 7 MOLECULAR WEIGHT ANALYSIS IN THE LIFE SCIENCES 72
DYNAMIC LIGHT SCATTERING METHOD 72
GEL PERMEATION CHROMATOGRAPHY 72
ZETA POTENTIAL 73
ULTRACENTRIFUGATION 73
REVENUE FROM ULTRACENTRIFUGATION ANALYSIS 74
TABLE 25 REVENUES FROM ULTRACENTRIFUGATION ANALYSIS OF NANOPARTICLES,
THROUGH 2019 ($ MILLIONS) 75
APPLICATIONS OF MOLECULAR WEIGHT INFORMATION 75
NANOPARTICLE MOLECULAR WEIGHT INSTRUMENTATION 76
TABLE 26 INSTRUMENTS FOR NANOPARTICLE MOLECULAR WEIGHT ANALYSIS 76
TABLE 27 ULTRACENTRIFUGATION INSTRUMENTATION FOR DETERMINATION OF
PARTICLE MOLECULAR WEIGHT 77
MAJOR PLAYERS IN MOLECULAR WEIGHT INSTRUMENTATION 78
TABLE 28 MAJOR PLAYERS IN NANOPARTICLE MOLECULAR WEIGHT
INSTRUMENTATION 78
CHAPTER 8 FLOW PROPERTIES OF NANOPARTICLES IN THE LIFE SCIENCES 80
APPLICATION OF VISCOSITY INFORMATION 81
MEASUREMENT OF RHEOLOGY/VISCOMETRY 82
TABLE 29 RHEOLOGY/VISCOSITY INSTRUMENTS IN THE LIFE SCIENCES 82
MAJOR PLAYERS IN THE RHEOLOGY/VISCOSITY MEASUREMENT 82
TABLE 30 MAJOR PLAYERS IN THE RHEOLOGY/VISCOSITY INSTRUMENT FOR THE
LIFE SCIENCES 83
CHAPTER 9 MOLECULAR STRUCTURE/IMAGING OF NANOPARTICLE IN THE LIFE
SCIENCES 85
SCANNING ELECTRON MICROSCOPE 85
TRANSMISSION ELECTRON MICROSCOPE 88
TABLE 31 REVENUES FROM TEM AND SEM INSTRUMENTATION FOR NANOPARTICLE
ANALYSIS, THROUGH 2019 ($ MILLIONS) 89
TABLE 32 COMPARISON OF SPECIFICATIONS FOR TEM, SEM AND OPTICAL
MICROSCOPES 89
SCANNING TUNNELING ELECTRON MICROSCOPE 90
ATOMIC FOCUS MICROSCOPE 91
Contact Mode 92
Lateral Force Mode 93
Tapping Mode 93
Noncontact Mode 93
Force Modulation Mode 94
CRYO-ELECTRON TOMOGRAPHY MICROSCOPY 94
REVENUE FROM AFM AND SPM ANALYSIS 95
TABLE 33 REVENUE FROM AFM AND SPM INSTRUMENTS FOR NANOPARTICLE
ANALYSIS, THROUGH 2019 ($ MILLIONS) 96
APPLICATION OF MOLECULAR STRUCTURE/ IMAGING INFORMATION 96
MOLECULAR STRUCTURE AND IMAGING INSTRUMENTATION 97
TABLE 34 INSTRUMENTATION FOR NANOPARTICLE ANALYSIS BY SEM AND TEM 97
TABLE 35 AFM INSTRUMENTS FOR NANOPARTICLE IMAGING ANALYSIS 100
MAJOR PLAYERS 101
TABLE 36 MAJOR PLAYERS IN THE TEM AND SEM INSTRUMENT MARKET 101
TABLE 37 MAJOR PLAYERS IN THE AFM INSTRUMENT MARKET 103
SCANNING TUNNELING MICROSCOPY 104
TABLE 38 SCANNING TUNNELING ELECTRON MICROSCOPES USED IN
NANOPARTICLE IDENTIFICATION 105
MAJOR PLAYERS IN STEM INSTRUMENT MARKET 106
TABLE 39 MAJOR PLAYERS IN STEM INSTRUMENT MARKET 106
CHAPTER 10 TRENDS AND OPPORTUNITIES IN NANOPARTICLE INSTRUMENTATION 108
ADVANCES IN NANOPARTICLE ANALYSIS IN LIFE SCIENCES 108
INDUSTRY DRIVERS 108
INDUSTRY INHIBITORS 109
FUTURE OPPORTUNITIES FOR NANOPARTICLES IN LIFE SCIENCES 109
CHAPTER 11 GLOBAL DEMAND FOR NANOPARTICLE ANALYSIS INSTRUMENTATION IN
LIFE SCIENCES 112
COUNTRIES INVOLVED IN NANOPARTICLE LIFE SCIENCE ACTIVITIES 112
TABLE 40 TOP COUNTRIES/REGIONS INVOLVED IN NANOPARTICLE LIFE SCIENCE
ACTIVITY 113
TABLE 41 NANOPARTICLE INSTRUMENTATION REVENUES AS PART OF TOTAL LIFE
SCIENCES NANOPARTICLE REVENUES, THROUGH 2019 ($ MILLIONS) 114
CHAPTER 12 NANOPARTICLE INSTRUMENT AND ASSOCIATED PATENTS 117
TABLE 42 RECENT U.S. PATENTS FOR NANOPARTICLE ANALYSIS AND DETECTION
METHODS 117
CHAPTER 13 DRUG CLINICAL TRIALS WITH NANOPARTICLE DRUGS 120
TABLE 43 NANOPARTICLE DRUG CLINICAL TRIALS WITHIN DISEASE CATEGORIES 120
TABLE 44 CLINICAL TRIALS WITH NANOPARTICLE CANCER DRUGS/PROCEDURES 121
TABLE 45 CLINICAL TRIALS FOR NANOPARTICLE NON-CANCER
DRUGS/PROCEDURES 132
TABLE 46 CLINICAL TRIALS WITH NANOPARTICLE DRUGS (MISCELLANEOUS) 135
TABLE 47 CLINICAL TRIALS FOR RESPIRATORY SYNCYTIAL VIRUS (RSV)
NANOPARTICLE VACCINE 136
TABLE 48 CLINICAL TRIALS FOR NANOPARTICLE FOR DIAGNOSTIC IMAGING 136
CHAPTER 14 NANOPARTICLE MERGERS AND ACQUISITIONS 138
CHAPTER 15 COMPANY PROFILES 144
ACCURION GMBH 144
PRODUCTS 144
TABLE 49 ACCURION INSTRUMENTS FOR NANOPARTICLE CHARACTERIZATION 145
STRATEGY 145
AGILENT TECHNOLOGIES INC. 145
PRODUCTS 146
TABLE 50 AGILENT TECHNOLOGIES INSTRUMENTS FOR NANOPARTICLE
CHARACTERIZATION 146
STRATEGY 146
ASPEX CORP. 147
PRODUCTS 147
TABLE 51 ASPEX INSTRUMENTATION USED FOR NANOPARTICLE ANALYSIS IN LIFE
SCIENCES 147
STRATEGY 148
ASYLUM RESEARCH 148
PRODUCTS 148
TABLE 52 ASYLUM RESEARCH AFM INSTRUMENTS USED IN NANOPARTICLE
CHARACTERIZATION 149
STRATEGY 149
BECKMAN-COULTER INC. 149
PRODUCTS 150
TABLE 53 BECKMAN COULTER PRODUCTS FOR NANOPARTICLE
CHARACTERIZATION 150
STRATEGY 150
BRUKER AXS INC. 151
PRODUCTS 151
TABLE 54 BRUKER AXS INSTRUMENTS FOR NANOPARTICLE CHARACTERIZATION
AND IDENTIFICATION 152
STRATEGY 152
CARL ZEISS SMT GMBH 152
PRODUCTS 153
TABLE 55 CARL ZEISS TEM AND SEM INSTRUMENTS USED FOR NANOPARTICLE
CHARACTERIZATION 153
STRATEGY 153
DME-DANISH MICRO ENGINEERING A/S 153
PRODUCTS 154
TABLE 56 DME PRODUCTS FOR NANOPARTICLE CHARACTERIZATION AND
IDENTIFICATION 154
STRATEGY 154
FEI CO. 155
PRODUCTS 155
TABLE 57 FEI ELECTRON MICROSCOPY PRODUCTS FOR NANOPARTICLE
EVALUATION 156
STRATEGY 156
FLUID IMAGING TECHNOLOGIES INC. 156
PRODUCTS 157
TABLE 58 FLUID IMAGING TECHNOLOGIES PRODUCTS FOR PHARMACEUTICAL
MONITORING 157
STRATEGY 157
HITACHI HIGH-TECHNOLOGIES CORP. 158
PRODUCTS 158
TABLE 59 HITACHI INSTRUMENTS FOR TEM AND SEM ANALYSIS OF
NANOPARTICLES 159
STRATEGY 159
HORIBA LTD. 159
PRODUCTS 160
TABLE 60 HORIBA INSTRUMENTS FOR NANOPARTICLE CHARACTERIZATION AND
IDENTIFICATION 160
STRATEGY 161
JEOL LTD. 161
PRODUCTS 161
TABLE 61 JEOL SEM AND TEM INSTRUMENTS FOR NANOPARTICLE
CHARACTERIZATION AND IDENTIFICATION 162
STRATEGY 162
MALVERN INSTRUMENTS LTD. 162
PRODUCTS 163
TABLE 62 MALVERN INSTRUMENTS EQUIPMENT THAT IS USED FOR NANOPARTICLE
CHARACTERIZATION 163
STRATEGY 164
MICROMETRICS INSTRUMENT CORP. 164
PRODUCTS 165
TABLE 63 NANOPARTICLE CHARACTERIZATION INSTRUMENTS FROM
MICROMETRICS 165
STRATEGY 165
NANOSIGHT LTD. 166
PRODUCTS 166
TABLE 64 NANOSIGHT NTA INSTRUMENTS 166
STRATEGY 167
NANOSURF AG 167
PRODUCTS 167
TABLE 65 NANOSURF INSTRUMENTS FOR AFM AND STM ANALYSIS OF
NANOPARTICLES 168
STRATEGY 168
OCCHIO SA 168
PRODUCTS 168
TABLE 66 OCCHIO SA INSTRUMENTS FOR NANOPARTICLE CHARACTERIZATION 169
STRATEGY 169
OMICRON NANOTECHNOLOGY GMBH 169
PRODUCTS 170
TABLE 67 OMICRON SCANNING TUNNELING MICROSCOPY INSTRUMENTS 170
STRATEGY 170
PARK SYSTEMS CORP. 170
PRODUCTS 171
TABLE 68 PARK SYSTEMS' AFM INSTRUMENTS FOR NANOPARTICLE
CHARACTERIZATION 171
STRATEGY 171
PARTICLE SIZING SYSTEMS INC. 171
PRODUCTS 172
TABLE 69 PARTICLE SIZING SYSTEMS NANOPARTICLE CHARACTERIZATION
INSTRUMENTATION 172
STRATEGY 172
PHENOM WORLD BV 173
PRODUCTS 173
TABLE 70 PHENOM WORLD SEM INSTRUMENTS FOR NANOPARTICLE ANALYSIS 173
STRATEGY 174
PHYSICA MCR 174
PRODUCTS 174
TABLE 71 PHYSICA MCR VISCOSITY INSTRUMENTATION USED FOR NANOPARTICLE
CHARACTERIZATION IN THE LIFE SCIENCES 175
STRATEGY 175
PHYSIK INSTRUMENTS GMBH 175
PRODUCTS 176
TABLE 72 PHYSIK INSTRUMENTS AFM MICROSCOPY ACCESSORIES 176
STRATEGY 176
TESCAN A.S. 176
PRODUCTS 177
TABLE 73 TESCAN INSTRUMENTS FOR NANOPARTICLE CHARACTERIZATION 177
STRATEGY 177
THERMO SORVALL DIVISION 177
PRODUCTS 178
TABLE 74 THERMO SORVALL ULTRACENTRIFUGES USED IN NANOPARTICLE
INVESTIGATIONS 178
STRATEGY 179
TSI INC. 179
PRODUCTS 180
TABLE 75 TSI INSTRUMENTS USED FOR NANOPARTICLE DETECTION 180
STRATEGY 180
UNISOKU CO. LTD. 180
PRODUCTS 181
TABLE 76 UNISOKU STEM INSTRUMENTS ON THE MARKET 181
STRATEGY 181
LIST OF TABLES
SUMMARY TABLE GLOBAL MARKET FOR LIFE SCIENCE NANOPARTICLE ANALYSIS
EQUIPMENT, THROUGH 2019 ($ MILLIONS) 8
TABLE 1 BIOPHARMA COMPANIES UTILIZING NANOPARTICLE CHARACTERIZATION
INSTRUMENTATION 20
TABLE 2 BIOPHARMA AND BIOTECHNOLOGY COMPANIES APPLYING NANOPARTICLE
TECHNOLOGY 22
TABLE 3 MARKET FOR NANOPARTICLES ANALYSIS EQUIPMENT, THROUGH 2019 ($
MILLIONS) 26
TABLE 4 PROJECTED GROWTH OF ANALYTICAL INSTRUMENTATION SEGMENTS,
2013-2014 (%) 27
TABLE 5 GLOBAL GROWTH RATE FOR ANALYTICAL/LIFE SCIENCES
INSTRUMENTATION BY REGION, 2014-2019 (%) 28
TABLE 6 BIOPHARMA COMPANIES UTILIZING NANOPARTICLE CHARACTERIZATION
INSTRUMENTATION 29
TABLE 7 COMPANIES SUPPORTING NANOPARTICLE USE IN THE LIFE SCIENCES 29
TABLE 8 REVENUE FROM NANOPARTICLE IDENTIFICATION INSTRUMENTATION,
THROUGH 2019 ($ MILLIONS) 33
TABLE 9 NANOPARTICLES CURRENTLY USED IN DRUG DELIVERY AND DIAGNOSTIC
IMAGING 34
TABLE 10 SPHERICITY LEVELS FOR NANOPARTICLE CHARACTERIZATION 35
TABLE 11 GOLD NANOPARTICLE SHAPES IN RESPONSE TO DNA BASES 36
TABLE 12 NANOPARTICLE SIZING METHODS USED IN PHARMACEUTICAL INDUSTRY 38
TABLE 13 STRENGTHS AND WEAKNESSES OF SOME NANOPARTICLE SIZING
METHODS 44
TABLE 14 NANOPARTICLE SIZING INSTRUMENTATION 48
TABLE 15 NANOPARTICLE SIZING MAJOR PLAYERS 50
TABLE 16 CHARACTERISTICS OF VARIOUS FORMS OF NANOPARTICLES 54
TABLE 17 COLOR CHANGE AS A FUNCTION OF PARTICLE SIZE FOR GOLD
NANOPARTICLES 55
TABLE 18 GOLD NANOPARTICLE SHAPES FORMED IN RESPONSE TO SPECIFIC DNA
BASES 56
TABLE 19 COLOR CHANGE AS A FUNCTION OF PARTICLE SIZE FOR SILVER
NANOPARTICLES 56
TABLE 20 ASPECT RATIOS FOR CERTAIN NANOPARTICLE SHAPES 58
TABLE 21 COMPARISON OF SPECIFICATION OF OPTICAL MICROSCOPE AND TEM 61
TABLE 22 COMPARISON OF SPECIFICATION OF A SEM TO OPTICAL MICROSCOPE 66
TABLE 23 NANOPARTICLE SHAPE INSTRUMENTS 67
TABLE 24 TEM AND SEM INSTRUMENTATION FOR NANOPARTICLE ANALYSIS 69
TABLE 25 REVENUES FROM ULTRACENTRIFUGATION ANALYSIS OF NANOPARTICLES,
THROUGH 2019 ($ MILLIONS) 75
TABLE 26 INSTRUMENTS FOR NANOPARTICLE MOLECULAR WEIGHT ANALYSIS 76
TABLE 27 ULTRACENTRIFUGATION INSTRUMENTATION FOR DETERMINATION OF
PARTICLE MOLECULAR WEIGHT 77
TABLE 28 MAJOR PLAYERS IN NANOPARTICLE MOLECULAR WEIGHT
INSTRUMENTATION 78
TABLE 29 RHEOLOGY/VISCOSITY INSTRUMENTS IN THE LIFE SCIENCES 82
TABLE 30 MAJOR PLAYERS IN THE RHEOLOGY/VISCOSITY INSTRUMENT FOR THE LIFE
SCIENCES 83
TABLE 31 REVENUES FROM TEM AND SEM INSTRUMENTATION FOR NANOPARTICLE
ANALYSIS, THROUGH 2019 ($ MILLIONS) 89
TABLE 32 COMPARISON OF SPECIFICATIONS FOR TEM, SEM AND OPTICAL
MICROSCOPES 89
TABLE 33 REVENUE FROM AFM AND SPM INSTRUMENTS FOR NANOPARTICLE
ANALYSIS, THROUGH 2019 ($ MILLIONS) 96
TABLE 34 INSTRUMENTATION FOR NANOPARTICLE ANALYSIS BY SEM AND TEM 97
TABLE 35 AFM INSTRUMENTS FOR NANOPARTICLE IMAGING ANALYSIS 100
TABLE 36 MAJOR PLAYERS IN THE TEM AND SEM INSTRUMENT MARKET 101
TABLE 37 MAJOR PLAYERS IN THE AFM INSTRUMENT MARKET 103
TABLE 38 SCANNING TUNNELING ELECTRON MICROSCOPES USED IN NANOPARTICLE
IDENTIFICATION 105
TABLE 39 MAJOR PLAYERS IN STEM INSTRUMENT MARKET 106
TABLE 40 TOP COUNTRIES/REGIONS INVOLVED IN NANOPARTICLE LIFE SCIENCE
ACTIVITY 113
TABLE 41 NANOPARTICLE INSTRUMENTATION REVENUES AS PART OF TOTAL LIFE
SCIENCES NANOPARTICLE REVENUES, THROUGH 2019 ($ MILLIONS) 114
TABLE 42 RECENT U.S. PATENTS FOR NANOPARTICLE ANALYSIS AND DETECTION
METHODS 117
TABLE 43 NANOPARTICLE DRUG CLINICAL TRIALS WITHIN DISEASE CATEGORIES 120
TABLE 44 CLINICAL TRIALS WITH NANOPARTICLE CANCER DRUGS/PROCEDURES 121
TABLE 45 CLINICAL TRIALS FOR NANOPARTICLE NON-CANCER DRUGS/PROCEDURES 132
TABLE 46 CLINICAL TRIALS WITH NANOPARTICLE DRUGS (MISCELLANEOUS) 135
TABLE 47 CLINICAL TRIALS FOR RESPIRATORY SYNCYTIAL VIRUS (RSV)
NANOPARTICLE VACCINE 136
TABLE 48 CLINICAL TRIALS FOR NANOPARTICLE FOR DIAGNOSTIC IMAGING 136
TABLE 49 ACCURION INSTRUMENTS FOR NANOPARTICLE CHARACTERIZATION 145
TABLE 50 AGILENT TECHNOLOGIES INSTRUMENTS FOR NANOPARTICLE
CHARACTERIZATION 146
TABLE 51 ASPEX INSTRUMENTATION USED FOR NANOPARTICLE ANALYSIS IN LIFE
SCIENCES 147
TABLE 52 ASYLUM RESEARCH AFM INSTRUMENTS USED IN NANOPARTICLE
CHARACTERIZATION 149
TABLE 53 BECKMAN COULTER PRODUCTS FOR NANOPARTICLE CHARACTERIZATION 150
TABLE 54 BRUKER AXS INSTRUMENTS FOR NANOPARTICLE CHARACTERIZATION
AND IDENTIFICATION 152
TABLE 55 CARL ZEISS TEM AND SEM INSTRUMENTS USED FOR NANOPARTICLE
CHARACTERIZATION 153
TABLE 56 DME PRODUCTS FOR NANOPARTICLE CHARACTERIZATION AND
IDENTIFICATION 154
TABLE 57 FEI ELECTRON MICROSCOPY PRODUCTS FOR NANOPARTICLE EVALUATION 156
TABLE 58 FLUID IMAGING TECHNOLOGIES PRODUCTS FOR PHARMACEUTICAL
MONITORING 157
TABLE 59 HITACHI INSTRUMENTS FOR TEM AND SEM ANALYSIS OF NANOPARTICLES 159
TABLE 60 HORIBA INSTRUMENTS FOR NANOPARTICLE CHARACTERIZATION AND
IDENTIFICATION 160
TABLE 61 JEOL SEM AND TEM INSTRUMENTS FOR NANOPARTICLE
CHARACTERIZATION AND IDENTIFICATION 162
TABLE 62 MALVERN INSTRUMENTS EQUIPMENT THAT IS USED FOR NANOPARTICLE
CHARACTERIZATION 163
TABLE 63 NANOPARTICLE CHARACTERIZATION INSTRUMENTS FROM MICROMETRICS 165
TABLE 64 NANOSIGHT NTA INSTRUMENTS 166
TABLE 65 NANOSURF INSTRUMENTS FOR AFM AND STM ANALYSIS OF
NANOPARTICLES 168
TABLE 66 OCCHIO SA INSTRUMENTS FOR NANOPARTICLE CHARACTERIZATION 169
TABLE 67 OMICRON SCANNING TUNNELING MICROSCOPY INSTRUMENTS 170
TABLE 68 PARK SYSTEMS' AFM INSTRUMENTS FOR NANOPARTICLE
CHARACTERIZATION 171
TABLE 69 PARTICLE SIZING SYSTEMS NANOPARTICLE CHARACTERIZATION
INSTRUMENTATION 172
TABLE 70 PHENOM WORLD SEM INSTRUMENTS FOR NANOPARTICLE ANALYSIS 173
TABLE 71 PHYSICA MCR VISCOSITY INSTRUMENTATION USED FOR NANOPARTICLE
CHARACTERIZATION IN THE LIFE SCIENCES 175
TABLE 72 PHYSIK INSTRUMENTS AFM MICROSCOPY ACCESSORIES 176
TABLE 73 TESCAN INSTRUMENTS FOR NANOPARTICLE CHARACTERIZATION 177
TABLE 74 THERMO SORVALL ULTRACENTRIFUGES USED IN NANOPARTICLE
INVESTIGATIONS 178
TABLE 75 TSI INSTRUMENTS USED FOR NANOPARTICLE DETECTION 180
TABLE 76 UNISOKU STEM INSTRUMENTS ON THE MARKET 181
LIST OF FIGURES
SUMMARY FIGURE GLOBAL MARKET FOR LIFE SCIENCE NANOPARTICLE ANALYSIS
EQUIPMENT, 2012-2019 ($ MILLIONS) 8

Date of Publication:
Aug 20, 2014
File Format:
PDF via E-mail
Number of Pages:
166 Pages
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